REC-1人非霍奇金淋巴瘤细胞(STR鉴定正确)

价 格:¥3000

期 货:现货(冻存管发2支)

保藏中心:BTCC

资源编号:BTCC-1405

产地:中国

套 餐:

T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

详细资料说明书下载质检报告(COA)

Cell line nameREC-1
SynonymsRec-1; REC 1; REC1; Rec1; rec1; REC
AccessionBTCC-1405
Resource Identification InitiativeTo cite this cell line use: REC-1 (RRID:CVCL_1884)
CommentsPart of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: LL-100 blood cancer cell line panel.
Part of: Lymphoma Research Foundation Mantle Cell Lymphoma cell bank (LRF MCL cell bank).
Part of: MD Anderson Cell Lines Project.
Population: Caucasian.
Doubling time: 38 hours (PubMed=25315077); ~38 hours (ATCC=CRL-3004); ~20-40 hours (DSMZ=ACC-584).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Omics: Virome analysis using RNAseq.
Caution: Wrongly indicated as originating from the lymph node of a 57 year old patient in ATCC.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=16448697).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gly245Asp (c.734G>A); ClinVar=VCV000012355; Zygosity=Heterozygous (DepMap).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln317Ter (c.949C>T); ClinVar=VCV000450344; Zygosity=Heterozygous (DepMap).
HLA typingSource: PubMed=25960936
Class I
HLA-AA*26:01,36:04
HLA-BB*35:01,57:01
HLA-CC*04:01,06:02
Class II
HLA-DQDQA1*01:02,01:02
HLA-DRDRB1*04:03,04:03

Source: PubMed=25688540
Class I
HLA-AA*01,03
HLA-BB*35,57
HLA-CC*04,06

Source: PubMed=26589293
Class I
HLA-AA*01:01,24:02
HLA-BB*35:01,57:01
HLA-CC*04:01,06:02
Class II
HLA-DQDQA1*01:02,01:02

DQB1*03:02,03:02
HLA-DRDRB1*01:01,01:01

Source: DSMZCellDive=ACC-584
Class I
HLA-BB*35:01:01,57:01:01
HLA-CC*04:01:01,06:02:01
Genome ancestrySource: PubMed=30894373

Origin% genome


African1.88
Native American0
East Asian, North2.34
East Asian, South0
South Asian0
European, North48.87
European, South46.91
DiseaseMantle cell lymphoma (NCIt: C4337)
Mantle cell lymphoma (ORDO: Orphanet_52416)
Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cellMale
Age at sampling61Y
CategoryCancer cell line
STR profileSource(s): ATCC; DSMZ; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133817
D3S135815,16
D5S81812,13
D7S82010,11
D8S117911,12
D13S31710
D16S53911
D18S5114,16
D19S43314,15
D21S1128,29
FGA22,23
Penta D9,13
Penta E7 (PubMed=25877200)
7,19 (DSMZ)
TH019,9.3
TPOX8,9
vWA17

Run an STR similarity search on this cell line
Web pageshttps://tcpaportal.org/mclp/
Publications

PubMed=1572647; DOI=10.1016/0888-7543(92)90303-A
Szepetowski P., Simon M.-P., Grosgeorge J., Huebner K., Bastard C., Evans G.A., Tsujimoto Y., Birnbaum D., Theillet C., Gaudray P.
Localization of 11q13 loci with respect to regional chromosomal breakpoints.
Genomics 12:738-744(1992)

PubMed=7504521; DOI=10.1002/gcc.2870080204
Raynaud S.D., Bekri S., Leroux D., Grosgeorge J., Klein B., Bastard C., Gaudray P., Simon M.-P.
Expanded range of 11q13 breakpoints with differing patterns of cyclin D1 expression in B-cell malignancies.
Genes Chromosomes Cancer 8:80-87(1993)

PubMed=8558920
Dirks W.G., Zaborski M., Jager K., Challier C., Shiota M., Quentmeier H., Drexler H.G.
The (2;5)(p23;q35) translocation in cell lines derived from malignant lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.
Leukemia 10:142-149(1996)

PubMed=14973505; DOI=10.1038/sj.leu.2403315
Prod'homme T., Drenou B., De Ruyffelaere C., Barbieri G., Wiszniewski W., Bastard C., Charron D., Alcaide-Loridan C.
Defective class II transactivator expression in a B lymphoma cell line.
Leukemia 18:832-840(2004)

PubMed=15126345; DOI=10.1158/0008-5472.CAN-03-3773
Ota A., Tagawa H., Karnan S., Tsuzuki S., Karpas A., Kira S., Yoshida Y., Seto M.
Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma.
Cancer Res. 64:3087-3095(2004)

PubMed=16448697; DOI=10.1016/j.leukres.2005.11.013
Camps J., Salaverria I., Garcia M.J., Prat E., Bea S., Pole J.C.M., Hernandez L., Del Rey J., Cigudosa J.C., Bernues M., Caldas C., Colomer D., Miro R., Campo E.
Genomic imbalances and patterns of karyotypic variability in mantle-cell lymphoma cell lines.
Leuk. Res. 30:923-934(2006)

PubMed=16960149; DOI=10.1182/blood-2006-06-026500
Mestre-Escorihuela C., Rubio-Moscardo F., Richter J.A., Siebert R., Climent J., Fresquet V., Beltran E., Agirre X., Marugan I., Marin M., Rosenwald A., Sugimoto K.-j., Wheat L.M., Karran E.L., Garcia J.F., Sanchez-Verde L., Prosper F., Staudt L.M., Pinkel D., Dyer M.J.S., Martinez-Climent J.A.
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.
Blood 109:271-280(2007)

PubMed=17332242; DOI=10.1182/blood-2006-11-057208
Pinyol M., Bea S., Pla L., Ribrag V., Bosq J., Rosenwald A., Campo E., Jares P.
Inactivation of RB1 in mantle-cell lymphoma detected by nonsense-mediated mRNA decay pathway inhibition and microarray analysis.
Blood 109:5422-5429(2007)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=21746927; DOI=10.1073/pnas.1018941108
Beltran E., Fresquet V., Martinez-Useros J., Richter-Larrea J.A., Sagardoy A., Sesma I., Almada L.L., Montes-Moreno S., Siebert R., Gesk S., Calasanz M.J., Malumbres R., Rieger M., Prosper F., Lossos I.S., Piris M.A., Fernandez-Zapico M.E., Martinez-Climent J.A.
A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma.
Proc. Natl. Acad. Sci. U.S.A. 108:12461-12466(2011)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24362935; DOI=10.1038/nm.3435
Rahal R., Frick M., Romero R., Korn J.M., Kridel R., Chan F.C., Meissner B., Bhang H.-E.C., Ruddy D., Kauffmann A., Farsidjani A., Derti A., Rakiec D., Naylor T., Pfister E., Kovats S., Kim S., Dietze K., Dorken B., Steidl C., Tzankov A., Hummel M., Monahan J., Morrissey M.P., Fritsch C., Sellers W.R., Cooke V.G., Gascoyne R.D., Lenz G., Stegmeier F.
Pharmacological and genomic profiling identifies NF-kappaB-targeted treatment strategies for mantle cell lymphoma.
Nat. Med. 20:87-92(2014)

PubMed=25960936; DOI=10.4161/21624011.2014.954893
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=25315077; DOI=10.3109/10428194.2014.970548
Fogli L.K., Williams M.E., Connors J.M., Reid Y.A., Brown K., O'Connor O.A.
Development and characterization of a Mantle Cell Lymphoma Cell Bank in the American Type Culture Collection.
Leuk. Lymphoma 56:2114-2122(2015)

PubMed=25355872; DOI=10.1128/JVI.02570-14
Cao S.-B., Strong M.J., Wang X., Moss W.N., Concha M., Lin Z., O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.
High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.
J. Virol. 89:713-729(2015)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25688540; DOI=10.1002/cyto.a.22643
Maiga S., Brosseau C., Descamps G., Dousset C., Gomez-Bougie P., Chiron D., Menoret E., Kervoelen C., Vie H., Cesbron A., Moreau-Aubry A., Amiot M., Pellat-Deceunynck C.
A simple flow cytometry-based barcode for routine authentication of multiple myeloma and mantle cell lymphoma cell lines.
Cytometry A 87:285-288(2015)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29666304; DOI=10.1158/1078-0432.CCR-17-3004
Pham L.V., Huang S.-J., Zhang H., Zhang J., Bell T., Zhou S.-H., Pogue E., Ding Z.-Y., Lam L., Westin J., Davis R.E., Young K.H., Medeiros L.J., Ford R.J. Jr., Nomie K., Zhang L., Wang M.
Strategic therapeutic targeting to overcome venetoclax resistance in aggressive B-cell lymphomas.
Clin. Cancer Res. 24:3967-3980(2018)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5
Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H., Koeffler H.P.
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)

PubMed=30629668; DOI=10.1371/journal.pone.0210404
Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.
Screening human cell lines for viral infections applying RNA-Seq data analysis.
PLoS ONE 14:E0210404-E0210404(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023
Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

Cross-references
Cell line collections (Providers)ATCC; CRL-3004
DSMZ; ACC-584
IZSLER; BS TCL 227
Cell line databases/resourcesCLO; CLO_0037056
cancercelllines; CVCL_1884
Cell_Model_Passport; SIDM01773
DepMap; ACH-000068
DSMZCellDive; ACC-584
IGRhCellID; REC1
LINCS_LDP; LCL-1123
Anatomy/cell type resourcesBTO; BTO:0003558
Biological sample resourcesBioSample; SAMN01821592
BioSample; SAMN01821658
BioSample; SAMN03471664
BioSample; SAMN10989553
Chemistry resourcesChEMBL-Cells; CHEMBL4482987
ChEMBL-Targets; CHEMBL4483266
PharmacoDB; REC1_1298_2019
PubChem_Cell_line; CVCL_1884
Encyclopedic resourcesWikidata; Q54949572
Experimental variables resourcesEFO; EFO_0002317
Gene expression databasesArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM95565
GEO; GSM95566
GEO; GSM95570
GEO; GSM104462
GEO; GSM104463
GEO; GSM115804
GEO; GSM155072
GEO; GSM155073
GEO; GSM155074
GEO; GSM629498
GEO; GSM629499
GEO; GSM887529
GEO; GSM888611
GEO; GSM1266771
GEO; GSM1266772
GEO; GSM2322622
GEO; GSM3150255
Polymorphism and mutation databasesCosmic; 1047111
Cosmic; 1086341
Cosmic; 1291033
Cosmic; 2088020
Cosmic; 2296993
Cosmic; 2756235
IARC_TP53; 25018
IARC_TP53; 30218
LiGeA; CCLE_530
Progenetix; CVCL_1884
Proteomic databasesPRIDE; PXD012087
Sequence databasesEGA; EGAS00001000610
EGA; EGAS00001002554
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number36

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