AML193人急性单核细胞白血病单核细胞(STR鉴定正确)

价 格:¥3600

期 货:现货(冻存管发2支)

保藏中心:BTCC

资源编号:BTCC-1433

产地:中国

套 餐:

T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

详细资料说明书下载质检报告(COA)

Cell line nameAML-193
SynonymsAML193
AccessionBTCC-1433
Resource Identification InitiativeTo cite this cell line use: AML-193 (RRID:BTCC-1433)
CommentsPart of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-9589.
Population: African American and Caucasian.
Characteristics: CSF2, IL3 and IL6 dependent.
Doubling time: 65 hours (PubMed=25984343); ~50-60 hours (DSMZ=ACC-549).
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; shRNA library screening.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Mutation; HGNC; HGNC:25657; BCORL1; Simple; p.Arg784Ter (c.2350C>T); Zygosity=Unspecified (PubMed=21989985; DepMap=ACH-000557).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly13Val (c.38G>T); ClinVar=VCV000375876; Zygosity=Heterozygous (PubMed=12068308; DepMap=ACH-000557).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.993+2T>G (IVS9+2T>G); ClinVar=VCV000635384; Zygosity=Unspecified; Note=Splice donor mutation (DepMap=ACH-000557).
HLA typingSource: PubMed=26589293
Class I
HLA-AA*68:02,74:01
HLA-BB*15:10,15:10
HLA-CC*03:02,08:02
Class II
HLA-DQDQA1*04:01,05:02

DQB1*06:07,06:07
HLA-DRDRB1*12:02,13:27
Genome ancestrySource: PubMed=30894373

Origin% genome


African65.28
Native American0
East Asian, North3.56
East Asian, South0
South Asian0
European, North14.42
European, South16.74
DiseaseChildhood acute myeloid leukemia (NCIt: C9160)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
HierarchyChildren:

CVCL_8441 (SR-91)
Sex of cellFemale
Age at sampling13Y
CategoryCancer cell line
STR profileSource(s): ATCC=CRL-9589; DSMZ=ACC-549

Markers:
AmelogeninX
CSF1PO11,12
D2S133819,20
D3S135816,17
D5S8189,13
D7S8209,12
D8S117913,15
D13S31712
D16S53912
D18S5113,14
D19S43314,15
D21S1130.2,31.2
FGA21,26 (ATCC=CRL-9589)
21,26.1 (DSMZ=ACC-549)
Penta D2.2,13 (ATCC=CRL-9589)
3,13 (DSMZ=ACC-549)
Penta E8,16
TH017,9
TPOX8,9
vWA15,17

Run an STR similarity search on this cell line
Web pagesInfo; -; -; https://web.archive.org/web/20201109215324/www.infarktforschung.de/macrophages_cell_lines.html
Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=AML-193
Publications

PubMed=3496132; DOI=10.1182/blood.V70.1.192.192
Lange B., Valtieri M., Santoli D., Caracciolo D., Mavilio F., Gemperlein I., Griffin C.A., Emanuel B.S., Finan J., Nowell P.C., Rovera G.
Growth factor requirements of childhood acute leukemia: establishment of GM-CSF-dependent cell lines.
Blood 70:192-199(1987)

PubMed=2656885; DOI=10.1002/stem.5530070202
Ihle J.N., Askew D.
Origins and properties of hematopoietic growth factor-dependent cell lines.
Int. J. Cell Cloning 7:68-91(1989)

PubMed=2015403; DOI=10.1182/blood.V77.8.1804.1804
Valtieri M., Boccoli G., Testa U., Barletta C., Peschle C.
Two-step differentiation of AML-193 leukemic line: terminal maturation is induced by positive interaction of retinoic acid with granulocyte colony-stimulating factor (CSF) and vitamin D3 with monocyte CSF.
Blood 77:1804-1812(1991)

PubMed=9195772; DOI=10.1016/s0925-5710(96)00563-4
Tohyama K.
Human factor-dependent leukemia cell lines.
Int. J. Hematol. 65:309-317(1997)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=12068308; DOI=10.1038/nature00766
Davies H.R., Bignell G.R., Cox C., Stephens P.J., Edkins S., Clegg S., Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C.S., Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J., Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T., Weber B.L., Seigler H.F., Darrow T.L., Paterson H.F., Marais R., Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=21989985; DOI=10.1182/blood-2011-05-356204; PMCID=PMC3228503
Li M., Collins R., Jiao Y.-C., Ouillette P., Bixby D., Erba H., Vogelstein B., Kinzler K.W., Papadopoulos N., Malek S.N.
Somatic mutations in the transcriptional corepressor gene BCORL1 in adult acute myelogenous leukemia.
Blood 118:5914-5917(2011)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035.1-140035.12(2014)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786
Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H.H., Koeffler H.P.
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)

PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144
Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.
Screening human cell lines for viral infections applying RNA-Seq data analysis.
PLoS ONE 14:e0210404.1-e0210404.22(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers)ATCC; CRL-9589
ATCC; HTB-188 - Discontinued
BCRJ; 0040 - Discontinued
DSMZ; ACC-549
Cell line databases/resourcesCLO; CLO_0001718
CLDB; cl272
cancercelllines; CVCL_1071
CCRID; 3101HUMTCHu207
Cell_Model_Passport; SIDM01525
DepMap; ACH-000557
DSMZCellDive; ACC-549
Lonza; 1685
Anatomy/cell type resourcesBTO; BTO_0006203
Biological sample resourcesBioSample; SAMN01821616
BioSample; SAMN03471219
BioSample; SAMN10987604
Chemistry resourcesPharmacoDB; AML193_61_2019
Encyclopedic resourcesWikidata; Q54749799
Experimental variables resourcesEFO; EFO_0022399
Gene expression databasesArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
GEO; GSM886867
GEO; GSM887932
Polymorphism and mutation databasesCosmic; 724816
Cosmic; 787420
Cosmic; 949089
Cosmic; 975238
Cosmic; 1012057
Cosmic; 1281305
Cosmic; 2306199
Cosmic; 2750853
IARC_TP53; 27144
LiGeA; CCLE_497
Progenetix; CVCL_1071

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